Info
| ID | 5980 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 8} |
| Abbreviation | 8a |
| SMILES | Cn1c(=O)c2nc3c4cccnc4c4ncccc4c3nc2n(C)c1=O.[c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1 |
TUCAN
C40H28IrN8O2/(1-34)(2-36)(3-39)(4-31)(5-45)(6-55)(7-33)(8-38)(9-37)(10-40)(11-32)(12-58)(13-54)(14-47)(15-57)(16-48)(17-53)(18-53)(19-42)(20-35)(21-54)(22-54)(23-43)(24-56)(25-44)(26-53)(27-46)(28-41)(29-37)(29-49)(30-40)(30-52)(31-33)(31-39)(32-34)(32-36)(33-59)(34-49)(35-41)(35-52)(36-37)(38-46)(38-62)(39-55)(40-45)(41-45)(42-46)(42-58)(43-47)(43-57)(44-48)(44-50)(47-51)(48-56)(49-59)(50-61)(50-65)(51-60)(51-64)(52-62)(53-71)(54-72)(55-73)(56-70)(57-74)(58-75)(59-73)(60-65)(60-74)(61-64)(61-69)(62-75)(63-66)(63-67)(63-76)(64-76)(65-70)(66-69)(66-71)(67-72)(67-77)(68-71)(68-72)(68-78)(73-79)(74-79)(75-79)(76-79)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| B16 | 25 | 8.2 | 10.1016/j.jinorgbio.2024.11280... | 2025 |
| A549 | 49 | 38 | 10.1016/j.jinorgbio.2024.11280... | 2025 |
| LO2 | — | — | 10.1016/j.jinorgbio.2024.11280... | 2025 |
🧬 Cell Death Types (4)
Apoptosis
high
«activation of caspase 3 and Bcl-2 family proteins to induce apoptosis»
Autophagy
high
«8a, 8b and 8c induced autophagy by inhibiting the AKT/PI3K/mTOR signaling pathway, downregulating p62 and promoting Beclin-1 expression upon light irradiation»
Ferroptosis
high
«The presence of Fer-1 was effective on increasing the cell survival, which demonstrates that the complexes possess the potential to induce ferroptosis»
Immunogenic Cell Death
medium
«upregulated the expression of the damage-associated molecules, HMGB1, CRT, and HSP70. The presence of Fer-1 was effective on increasing the cell survival, which demonstrates that the complexes possess...»