Info
| ID | 5978 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 8} |
| Abbreviation | Ir5 |
| SMILES | CN1CCN(c2ccc(-c3nc4c5cccnc5c5ncccc5c4[nH]3)cc2)CC1.Fc1[c-]c(-c2ccccn2)cc(F)c1.Fc1[c-]c(-c2ccccn2)cc(F)c1 |
TUCAN
C46H34F4IrN8/(1-40)(2-38)(3-42)(4-64)(5-51)(6-50)(7-41)(8-37)(9-63)(10-45)(11-61)(12-54)(13-52)(14-46)(15-60)(16-60)(17-67)(18-60)(19-62)(20-65)(21-65)(22-44)(23-53)(24-67)(25-39)(26-49)(27-68)(28-48)(29-66)(30-66)(31-43)(32-68)(33-47)(34-82)(35-55)(35-79)(36-56)(36-80)(37-40)(37-61)(38-55)(38-77)(39-77)(39-79)(40-41)(41-69)(42-45)(42-72)(43-53)(43-63)(44-52)(44-72)(45-57)(46-51)(46-75)(47-56)(47-78)(48-78)(48-80)(49-51)(49-62)(50-54)(50-59)(52-57)(53-58)(54-64)(55-69)(56-75)(57-76)(58-70)(58-73)(59-71)(59-74)(60-84)(61-85)(62-87)(63-81)(64-88)(65-67)(65-83)(66-68)(66-83)(67-84)(68-84)(69-85)(70-74)(70-81)(71-73)(71-86)(72-83)(73-82)(74-88)(75-87)(76-82)(76-86)(77-89)(78-91)(79-90)(80-92)(85-93)(86-93)(87-93)(88-93)
Measurements (1)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A375 | — | 11 | 10.1002/adhm.202301227 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«They target mitochondria in human melanoma tumor cells and trigger apoptosis related to mitochondrial dysfunction upon irradiation.»