Info
| ID | 5976 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 2 |
| Donor atoms | {"N": 7} |
| Abbreviation | Ir3 |
| SMILES | C[N+]1(C)CCN(c2ccc(-c3nc4c5cccnc5c5ncccc5c4[nH]3)cc2)CC1.[c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1 |
TUCAN
C47H41IrN8/(1-46)(2-48)(3-44)(4-58)(5-50)(6-73)(7-45)(8-77)(9-74)(10-47)(11-49)(12-61)(13-79)(14-63)(15-77)(16-79)(17-78)(18-71)(19-71)(20-71)(21-80)(22-72)(23-72)(24-78)(25-72)(26-51)(27-65)(28-75)(29-52)(30-80)(31-64)(32-60)(33-56)(34-54)(35-55)(36-76)(37-53)(38-59)(39-57)(40-62)(41-90)(42-45)(42-66)(43-49)(43-67)(44-46)(44-50)(45-50)(46-66)(47-56)(47-73)(48-58)(48-67)(49-63)(51-54)(51-70)(52-53)(52-68)(53-75)(54-87)(55-65)(55-69)(56-61)(57-60)(57-62)(58-63)(59-64)(59-87)(60-74)(61-81)(62-82)(64-70)(65-76)(66-81)(67-82)(68-83)(68-84)(69-85)(69-86)(70-88)(71-92)(72-92)(73-93)(74-94)(75-89)(76-96)(77-79)(77-92)(78-80)(78-92)(79-91)(80-91)(81-93)(82-94)(83-85)(83-90)(84-86)(84-89)(85-95)(86-96)(87-91)(88-90)(88-95)(93-97)(94-97)(95-97)(96-97)
Measurements (1)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A375 | 1.3e+02 | 3.1 | 10.1002/adhm.202301227 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«They target mitochondria in human melanoma tumor cells and trigger apoptosis related to mitochondrial dysfunction upon irradiation.»