Info
| ID | 5973 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 5} |
| Abbreviation | Ir-PTS-3 |
| SMILES | COc1cc(/C=C/c2ccc(OCC(=O)NCc3ccnc(-c4cc(C)ccn4)c3)cc2)cc(OC)c1.[c-]1cccc2ccc3cccnc3c12.[c-]1cccc2ccc3cccnc3c12 |
TUCAN
C56H45IrN5O4/(1-86)(2-46)(3-63)(4-46)(5-55)(6-57)(7-51)(8-49)(9-97)(10-87)(11-56)(12-46)(13-50)(14-74)(15-73)(16-96)(17-61)(18-69)(19-65)(20-96)(21-96)(22-90)(23-89)(24-88)(25-75)(26-64)(27-68)(28-95)(29-66)(30-58)(31-54)(32-59)(33-97)(34-90)(35-70)(36-62)(37-67)(38-71)(39-72)(40-95)(41-95)(42-60)(43-52)(44-53)(45-102)(46-82)(47-51)(47-78)(48-52)(48-83)(49-57)(49-79)(50-55)(50-76)(51-54)(52-72)(53-59)(53-80)(54-56)(55-86)(56-79)(57-76)(58-60)(58-87)(59-77)(60-77)(61-65)(61-81)(62-82)(62-88)(63-82)(63-92)(64-84)(64-99)(65-98)(66-99)(66-100)(67-85)(67-93)(68-72)(68-80)(69-74)(69-81)(70-85)(70-89)(71-75)(71-81)(73-84)(73-100)(74-84)(75-98)(76-91)(77-94)(78-79)(78-91)(80-83)(83-94)(85-90)(86-103)(87-104)(88-105)(89-106)(90-102)(91-103)(92-93)(92-105)(93-106)(94-104)(95-108)(96-110)(97-101)(97-109)(98-109)(99-108)(100-110)(101-102)(101-107)(103-111)(104-111)(105-111)(106-111)(110-111)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 4.7 | — | 10.1016/j.jinorgbio.2023.11242... | 2024 |
| 4T1 | 5.1 | — | 10.1016/j.jinorgbio.2023.11242... | 2024 |
| MCF-10A | 12 | — | 10.1016/j.jinorgbio.2023.11242... | 2024 |
🧬 Cell Death Types (1)
Autophagy
high
«eventually leading to autophagic cell death»