Info
| ID | 5972 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 5} |
| Abbreviation | Ir-PTS-2 |
| SMILES | COc1cc(/C=C/c2ccc(OCC(=O)NCc3ccnc(-c4cc(C)ccn4)c3)cc2)cc(OC)c1.[c-]1ccsc1-c1ccccn1.[c-]1ccsc1-c1ccccn1 |
TUCAN
C48H41IrN5O4S2/(1-47)(2-48)(3-60)(4-81)(5-74)(6-62)(7-70)(8-49)(9-52)(10-45)(11-42)(12-59)(13-57)(14-54)(15-63)(16-71)(17-58)(18-74)(19-55)(20-50)(21-86)(22-87)(23-79)(24-80)(25-64)(26-61)(27-79)(28-73)(29-46)(30-42)(31-81)(32-72)(33-80)(34-53)(35-79)(36-51)(37-42)(38-65)(39-56)(40-80)(41-90)(42-69)(43-45)(43-88)(44-46)(44-89)(45-86)(46-87)(47-48)(47-75)(48-50)(49-52)(49-77)(50-70)(51-52)(51-73)(53-54)(53-67)(54-68)(55-62)(55-67)(56-66)(56-72)(57-82)(57-83)(58-66)(58-76)(59-69)(59-71)(60-68)(60-82)(61-65)(61-67)(62-84)(63-69)(63-78)(64-68)(64-83)(65-84)(66-74)(70-93)(71-92)(72-91)(73-94)(74-90)(75-88)(75-93)(76-78)(76-91)(77-89)(77-94)(78-92)(79-96)(80-98)(81-85)(81-97)(82-96)(83-98)(84-97)(85-90)(85-95)(86-99)(87-100)(88-99)(89-100)(91-101)(92-101)(93-101)(94-101)(98-101)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 4.6 | — | 10.1016/j.jinorgbio.2023.11242... | 2024 |
| MCF-10A | 5.4 | — | 10.1016/j.jinorgbio.2023.11242... | 2024 |
| 4T1 | 5.6 | — | 10.1016/j.jinorgbio.2023.11242... | 2024 |
🧬 Cell Death Types (1)
Autophagy
high
«eventually leading to autophagic cell death»