Info
| ID | 5967 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | 2c |
| SMILES | Nc1nc(Cl)c(-c2nc3c4cccnc4c4ncccc4c3[nH]2)c(Cl)n1.[c-]1ccccc1-c1nccc2ccccc12.[c-]1ccccc1-c1nccc2ccccc12 |
TUCAN
C47H29Cl2IrN9/(1-32)(2-33)(3-34)(4-38)(5-36)(6-37)(7-35)(8-46)(9-40)(10-43)(11-53)(12-66)(13-42)(14-44)(15-45)(16-50)(17-52)(18-39)(19-49)(20-63)(21-41)(22-64)(23-65)(24-47)(25-51)(26-48)(27-77)(28-77)(29-81)(30-37)(30-57)(31-47)(31-58)(32-34)(32-35)(33-35)(33-54)(34-55)(36-37)(36-43)(38-40)(38-56)(39-40)(39-48)(41-42)(41-62)(42-63)(43-46)(44-55)(44-64)(45-61)(45-65)(46-57)(47-50)(48-61)(49-53)(49-66)(50-51)(51-52)(52-58)(53-60)(54-55)(54-67)(56-61)(56-70)(57-67)(58-70)(59-73)(59-75)(59-76)(60-71)(60-72)(62-68)(62-69)(63-78)(64-82)(65-83)(66-79)(67-82)(68-71)(68-81)(69-72)(69-78)(70-83)(71-84)(72-79)(73-81)(73-84)(74-77)(74-80)(74-85)(75-80)(75-86)(76-85)(76-87)(82-88)(83-88)(84-88)(85-88)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 2.2 | — | 10.1016/j.ejmech.2024.116295 | 2024 |
| B16 | 2.5 | — | 10.1016/j.ejmech.2024.116295 | 2024 |
| HCT-116 | 2.5 | — | 10.1016/j.ejmech.2024.116295 | 2024 |
| HepG2 | 3.1 | — | 10.1016/j.ejmech.2024.116295 | 2024 |
| LO2 | 35 | — | 10.1016/j.ejmech.2024.116295 | 2024 |
🧬 Cell Death Types (3)
Apoptosis
high
«Complex 2c induce an early apoptosis, while 2a and 2b cause a late apoptosis.»
Ferroptosis
high
«ferroptosis was investigated through measurements of intracellular glutathione (GSH), malondialdehyde (MDA), and recombinant glutathione peroxidase (GPX4) protein expression.»
Pyroptosis
high
«The pyroptosis was explored via cell morphology, release of lactate dehydrogenase (LDH) and expression of pyroptosis-related proteins.»