Info
| ID | 5963 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"O": 1, "N": 6} |
| Abbreviation | 1b |
| SMILES | O=[N+]([O-])c1ccccc1-c1nc2c3cccnc3c3ncccc3c2[nH]1.[c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1 |
TUCAN
C41H27IrN7O2/(1-57)(2-31)(3-30)(4-41)(5-45)(6-32)(7-50)(8-34)(9-58)(10-43)(11-44)(12-51)(13-38)(14-40)(15-59)(16-48)(17-35)(18-49)(19-36)(20-47)(21-37)(22-39)(23-60)(24-33)(25-46)(26-42)(27-70)(28-44)(28-52)(29-46)(29-53)(30-32)(30-57)(31-33)(31-44)(32-34)(33-35)(34-61)(35-52)(36-42)(36-53)(37-38)(37-55)(38-47)(39-40)(39-59)(40-54)(41-48)(41-56)(42-49)(43-50)(43-67)(45-50)(45-58)(46-49)(47-51)(48-60)(51-63)(52-61)(53-67)(54-64)(54-65)(55-63)(55-68)(56-62)(56-66)(57-72)(58-73)(59-75)(60-69)(61-72)(62-65)(62-69)(63-71)(64-66)(64-74)(65-75)(66-70)(67-73)(68-70)(68-74)(71-76)(71-77)(72-78)(73-78)(74-78)(75-78)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HepG2 | 78 | — | 10.1016/j.ejmech.2023.116078 | 2024 |
| BEL-7402 | — | — | 10.1016/j.ejmech.2023.116078 | 2024 |
| SK-Hep1 | — | — | 10.1016/j.ejmech.2023.116078 | 2024 |
| LO2 | — | — | 10.1016/j.ejmech.2023.116078 | 2024 |
🧬 Cell Death Types (3)
Apoptosis
medium
«Abstract: 'Taken together, the liposomes or targeted liposomes encapsulated compounds trigger cell death by way of apoptosis, autophagy, ferroptosis' and experiments on mitochondrial membrane potentia...»
Autophagy
medium
«Abstract: 'Taken together, the liposomes or targeted liposomes encapsulated compounds trigger cell death by way of ... autophagy' and RNA-seq was used to examine signaling pathways, but no specific au...»
Ferroptosis
high
«Title: 'induce cell death via ferroptosis on HepG2 cells.' Abstract: 'Taken together, the liposomes or targeted liposomes encapsulated compounds trigger cell death by way of ... ferroptosis'»