Info
| ID | 5962 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ir2 |
| SMILES | OC[C@@H]1O[C@H](Oc2ccccc2-c2nc3c4cccnc4c4ncccc4c3[nH]2)[C@@H](O)[C@H](O)[C@H]1O.[c-]1ccccc1-c1nccc2ccccc12.[c-]1ccccc1-c1nccc2ccccc12 |
TUCAN
C55H42IrN6O6/(1-46)(2-50)(3-45)(4-94)(5-48)(6-49)(7-80)(8-47)(9-57)(10-52)(11-60)(12-58)(13-81)(14-53)(15-69)(16-91)(17-91)(18-61)(19-96)(20-97)(21-55)(22-64)(23-83)(24-95)(25-51)(26-56)(27-59)(28-54)(29-93)(30-68)(31-63)(32-70)(33-82)(34-65)(35-67)(36-62)(37-66)(38-99)(39-106)(40-108)(41-105)(42-104)(43-51)(43-71)(44-65)(44-72)(45-46)(45-52)(46-50)(47-58)(47-67)(48-74)(48-80)(49-57)(49-71)(50-73)(51-56)(52-74)(53-79)(53-81)(54-62)(54-76)(55-63)(55-75)(56-57)(58-79)(59-67)(59-78)(60-68)(60-72)(61-69)(61-92)(62-83)(63-69)(64-70)(64-82)(65-66)(66-68)(70-77)(71-84)(72-85)(73-74)(73-84)(75-90)(75-92)(76-87)(76-88)(77-86)(77-89)(78-79)(78-85)(80-100)(81-101)(82-102)(83-98)(84-100)(85-101)(86-88)(86-102)(87-89)(87-99)(88-98)(89-103)(90-99)(90-103)(91-96)(91-108)(92-107)(93-94)(93-95)(93-106)(94-96)(94-105)(95-97)(95-104)(96-109)(97-107)(97-109)(100-110)(101-110)(102-110)(103-110)(108-110)(109-110)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| BEL-7402 | — | 5 | 10.1016/j.jinorgbio.2022.11197... | 2022 |
| A549 | — | 0.2 | 10.1016/j.jinorgbio.2022.11197... | 2022 |
| HCT-116 | — | 0.8 | 10.1016/j.jinorgbio.2022.11197... | 2022 |
| B16 | — | 32 | 10.1016/j.jinorgbio.2022.11197... | 2022 |
| LO2 | — | 26 | 10.1016/j.jinorgbio.2022.11197... | 2022 |
🧬 Cell Death Types (2)
Apoptosis
high
«The cellular uptake, endoplasmic reticulum and mitochondria localization, reactive oxygen species, the change of mitochondrial membrane potential, γ-H2AX levels, cycle arrest, apoptosis and the expres...»
Immunogenic Cell Death
high
«The calreticulin (CRT), heat shock protein 70 (HSP70), high mobility group box 1 (HMGB1) were explored. This study demonstrates that photoactivatable complexes induce cell death in A549 through ... im...»