Info
| ID | 5961 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ir1 |
| SMILES | OC[C@@H]1O[C@H](Oc2ccccc2-c2nc3c4cccnc4c4ncccc4c3[nH]2)[C@@H](O)[C@H](O)[C@H]1O.[c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1 |
TUCAN
C47H38IrN6O6/(1-45)(2-68)(3-46)(4-54)(5-69)(6-43)(7-70)(8-81)(9-59)(10-41)(11-50)(12-51)(13-82)(14-44)(15-42)(16-55)(17-52)(18-79)(19-79)(20-85)(21-56)(22-60)(23-57)(24-83)(25-48)(26-58)(27-47)(28-84)(29-61)(30-53)(31-62)(32-49)(33-71)(34-87)(35-92)(36-93)(37-96)(38-94)(39-41)(39-63)(40-47)(40-67)(41-43)(42-46)(42-72)(43-51)(44-51)(44-63)(45-46)(45-68)(47-59)(48-49)(48-50)(49-76)(50-70)(52-55)(52-67)(53-56)(53-60)(54-58)(54-64)(55-59)(56-61)(57-62)(57-69)(58-71)(60-66)(61-80)(62-65)(63-72)(64-73)(64-74)(65-75)(65-77)(66-78)(66-80)(67-76)(68-89)(69-91)(70-90)(71-86)(72-89)(73-75)(73-87)(74-77)(74-86)(75-88)(76-90)(77-91)(78-87)(78-88)(79-84)(79-96)(80-95)(81-82)(81-83)(81-92)(82-84)(82-94)(83-85)(83-93)(84-97)(85-95)(85-97)(88-98)(89-98)(90-98)(91-98)(96-98)(97-98)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| BEL-7402 | — | 31 | 10.1016/j.jinorgbio.2022.11197... | 2022 |
| A549 | — | 17 | 10.1016/j.jinorgbio.2022.11197... | 2022 |
| HCT-116 | — | 18 | 10.1016/j.jinorgbio.2022.11197... | 2022 |
| B16 | — | 36 | 10.1016/j.jinorgbio.2022.11197... | 2022 |
| LO2 | — | — | 10.1016/j.jinorgbio.2022.11197... | 2022 |
🧬 Cell Death Types (2)
Apoptosis
high
«The cellular uptake, endoplasmic reticulum and mitochondria localization, reactive oxygen species, the change of mitochondrial membrane potential, γ-H2AX levels, cycle arrest, apoptosis and the expres...»
Immunogenic Cell Death
high
«The calreticulin (CRT), heat shock protein 70 (HSP70), high mobility group box 1 (HMGB1) were explored. This study demonstrates that photoactivatable complexes induce cell death in A549 through ... im...»