Info
| ID | 5960 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ir2 |
| SMILES | CC(=O)CC(O)c1cc(Br)c(-c2nc3c4cccnc4c4ncccc4c3[nH]2)cc1Br.[c-]1ccccc1-c1nccc2ccccc12.[c-]1ccccc1-c1nccc2ccccc12 |
TUCAN
C53H36Br2IrN6O2/(1-87)(2-43)(3-48)(4-40)(5-41)(6-42)(7-44)(8-52)(9-75)(10-54)(11-59)(12-46)(13-49)(14-37)(15-64)(16-64)(17-63)(18-55)(19-76)(20-50)(21-77)(22-51)(23-53)(24-56)(25-45)(26-37)(27-61)(28-78)(29-57)(30-58)(31-60)(32-62)(33-47)(34-37)(35-91)(36-97)(37-86)(38-48)(38-67)(39-54)(39-71)(40-41)(40-43)(41-42)(42-65)(43-66)(44-66)(44-75)(45-59)(45-68)(46-48)(46-53)(47-68)(47-77)(49-52)(49-69)(50-73)(50-88)(51-53)(51-67)(52-59)(54-60)(55-61)(55-78)(56-62)(56-70)(57-58)(57-71)(58-60)(61-74)(62-76)(63-72)(63-89)(64-86)(64-87)(65-66)(65-79)(67-79)(68-69)(69-83)(70-80)(70-81)(71-83)(72-87)(72-88)(73-85)(73-89)(74-82)(74-84)(75-92)(76-90)(77-95)(78-94)(79-92)(80-84)(80-91)(81-82)(81-90)(82-94)(83-95)(84-93)(85-91)(85-93)(86-96)(87-97)(88-98)(89-99)(92-100)(93-100)(94-100)(95-100)(97-100)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| SGC-7901 | — | — | 10.1016/j.jinorgbio.2023.11213... | 2023 |
| HepG2 | — | — | 10.1016/j.jinorgbio.2023.11213... | 2023 |
| A549 | — | — | 10.1016/j.jinorgbio.2023.11213... | 2023 |
| HeLa | — | — | 10.1016/j.jinorgbio.2023.11213... | 2023 |
| B16 | — | — | 10.1016/j.jinorgbio.2023.11213... | 2023 |
| NIH-3T3 | — | — | 10.1016/j.jinorgbio.2023.11213... | 2023 |
🧬 Cell Death Types (3)
Apoptosis
high
«The cellular uptake, endoplasmic reticulum (ER) localization, autophagy, tubulin polymerization, glutathione (GSH), malondialdehyde (MDA) and release of cytochrome c were investigated to explore the m...»
Autophagy
high
«The cellular uptake, endoplasmic reticulum (ER) localization, autophagy, tubulin polymerization, glutathione (GSH), malondialdehyde (MDA) and release of cytochrome c were investigated to explore the m...»
Immunogenic Cell Death
high
«The calreticulin (CRT), heat shock protein 70 (HSP70), high mobility group box 1 (HMGB1) were also explored. The results demonstrated that Ir1lipo and Ir2lipo induce ... immunogenic cell death (ICD).»