Info
| ID | 5958 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ir2 |
| SMILES | CC(C)(C)c1cc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)c(O)c(C(C)(C)C)c1.[c-]1cccc2ccc3cccnc3c12.[c-]1cccc2ccc3cccnc3c12 |
TUCAN
C53H44IrN6O/(1-68)(2-89)(3-86)(4-53)(5-70)(6-71)(7-57)(8-59)(9-58)(10-56)(11-65)(12-87)(13-88)(14-72)(15-45)(16-45)(17-61)(18-45)(19-46)(20-64)(21-63)(22-46)(23-48)(24-48)(25-48)(26-49)(27-62)(28-66)(29-55)(30-60)(31-46)(32-47)(33-49)(34-49)(35-50)(36-50)(37-50)(38-69)(39-54)(40-67)(41-47)(42-47)(43-99)(44-104)(45-84)(46-84)(47-84)(48-85)(49-85)(50-85)(51-53)(51-74)(52-65)(52-80)(53-59)(54-55)(54-76)(55-73)(56-59)(56-76)(57-70)(57-73)(58-71)(58-75)(60-67)(60-75)(61-77)(61-78)(62-78)(62-83)(63-64)(63-86)(64-79)(65-69)(66-69)(66-82)(67-82)(68-72)(68-89)(70-87)(71-88)(72-81)(73-90)(74-76)(74-90)(75-94)(77-96)(77-97)(78-84)(79-92)(79-93)(80-82)(80-94)(81-91)(81-95)(83-85)(83-97)(86-103)(87-100)(88-101)(89-98)(90-100)(91-92)(91-98)(92-103)(93-95)(93-102)(94-101)(95-99)(96-99)(96-102)(97-104)(100-105)(101-105)(102-105)(103-105)(104-105)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| BEL-7402 | 9.8 | — | 10.1016/j.jinorgbio.2023.11214... | 2023 |
| HeLa | 26 | — | 10.1016/j.jinorgbio.2023.11214... | 2023 |
| A549 | — | — | 10.1016/j.jinorgbio.2023.11214... | 2023 |
| HepG2 | — | — | 10.1016/j.jinorgbio.2023.11214... | 2023 |
| LO2 | — | — | 10.1016/j.jinorgbio.2023.11214... | 2023 |
🧬 Cell Death Types (2)
Apoptosis
high
«Ir1 and Ir2 induced apoptosis by changing the mitochondrial membrane potential, Ca2+ release, ROS accumulation, and cell cycle arrest at the S phase.»
Autophagy
high
«increased the expression of autophagy-related proteins of Beclin-1 and LC3-II.»