Info
| ID | 5956 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | Ir-4 |
| SMILES | [c-]1c(-c2ccccn2)sc2ccccc12.[c-]1c(-c2ccccn2)sc2ccccc12.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C38H24IrN4S2/(1-51)(2-32)(3-28)(4-41)(5-53)(6-30)(7-31)(8-40)(9-33)(10-44)(11-29)(12-27)(13-45)(14-38)(15-39)(16-37)(17-52)(18-54)(19-35)(20-34)(21-42)(22-36)(23-43)(24-46)(25-47)(25-59)(26-50)(26-60)(27-35)(27-48)(28-29)(28-31)(29-55)(30-38)(30-47)(31-52)(32-38)(32-40)(33-41)(33-51)(34-39)(34-54)(35-49)(36-39)(36-58)(37-43)(37-50)(40-61)(41-48)(42-45)(42-49)(43-46)(44-46)(44-62)(45-53)(47-61)(48-56)(49-57)(50-62)(51-63)(52-64)(53-65)(54-66)(55-59)(55-64)(56-57)(56-63)(57-65)(58-60)(58-66)(59-67)(60-68)(61-67)(62-68)(63-69)(64-69)(65-69)(66-69)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 18 | — | 10.1016/j.jinorgbio.2022.11205... | 2023 |
| A549cisR | 35 | — | 10.1016/j.jinorgbio.2022.11205... | 2023 |
| LO2 | 74 | — | 10.1016/j.jinorgbio.2022.11205... | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«The flow cytometry investigations demonstrated that Ir-1 and Ir-3 can arrest the cell cycle in S phase and induce the cell death through apoptosis process.»