Info
| ID | 5955 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 7, "O": 1} |
| Abbreviation | Ir-3 |
| SMILES | O=C(Nc1cc2cccnc2c2ncccc12)OCCCCCCSc1ccc([N+](=O)[O-])c2nonc12.[c-]1c(-c2ccccn2)sc2ccccc12.[c-]1c(-c2ccccn2)sc2ccccc12 |
TUCAN
C51H38IrN8O5S3/(1-57)(2-51)(3-82)(4-63)(5-70)(6-41)(7-62)(8-65)(9-71)(10-55)(11-43)(12-62)(13-47)(14-54)(15-56)(16-46)(17-48)(18-45)(19-49)(20-58)(21-84)(22-53)(23-63)(24-59)(25-82)(26-73)(27-64)(28-61)(29-44)(30-84)(31-72)(32-64)(33-42)(34-52)(35-60)(36-50)(37-65)(38-90)(39-67)(39-85)(40-66)(40-86)(41-44)(41-89)(42-43)(42-48)(43-59)(44-58)(45-46)(45-47)(46-74)(47-70)(48-87)(49-50)(49-69)(50-73)(51-52)(51-88)(52-75)(53-60)(53-72)(54-56)(54-71)(55-58)(55-66)(56-57)(57-80)(59-67)(60-68)(61-69)(61-77)(62-63)(62-84)(63-64)(64-65)(65-82)(66-89)(67-87)(68-77)(68-78)(69-81)(70-95)(71-94)(72-96)(73-97)(74-86)(74-95)(75-79)(75-93)(76-79)(76-88)(76-92)(77-90)(78-81)(78-96)(79-91)(80-85)(80-94)(81-97)(82-101)(83-90)(83-98)(83-101)(84-104)(85-103)(86-105)(87-103)(88-104)(89-105)(91-102)(92-102)(93-99)(93-100)(94-106)(95-106)(96-106)(97-106)(101-106)(102-106)(104-106)(105-106)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 8.2 | — | 10.1016/j.jinorgbio.2022.11205... | 2023 |
| A549cisR | 9.6 | — | 10.1016/j.jinorgbio.2022.11205... | 2023 |
| LO2 | 58 | — | 10.1016/j.jinorgbio.2022.11205... | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«The flow cytometry investigations demonstrated that Ir-1 and Ir-3 can arrest the cell cycle in S phase and induce the cell death through apoptosis process.»