Info
| ID | 5953 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | 4b |
| SMILES | Nc1nc(N)c2nc3c4cccnc4c4ncccc4c3nc2n1.[c-]1ccccc1-c1nccc2ccccc12.[c-]1ccccc1-c1nccc2ccccc12 |
TUCAN
C46H30IrN10/(1-38)(2-33)(3-36)(4-40)(5-52)(6-49)(7-37)(8-43)(9-63)(10-45)(11-54)(12-48)(13-64)(14-42)(15-34)(16-53)(17-51)(18-50)(19-39)(20-65)(21-41)(22-35)(23-44)(24-46)(25-66)(26-47)(27-78)(28-78)(29-77)(30-77)(31-36)(31-58)(32-43)(32-60)(33-40)(33-55)(34-35)(34-40)(35-59)(36-38)(37-38)(37-49)(39-47)(39-56)(41-42)(41-64)(42-57)(43-52)(44-53)(44-61)(45-59)(45-63)(46-51)(46-52)(47-53)(48-54)(48-62)(49-58)(50-61)(50-66)(51-60)(54-65)(55-59)(55-67)(56-61)(56-71)(57-72)(57-73)(58-67)(60-71)(62-68)(62-69)(63-83)(64-81)(65-82)(66-84)(67-83)(68-72)(68-86)(69-73)(69-82)(70-74)(70-75)(70-86)(71-84)(72-80)(73-81)(74-79)(74-80)(75-78)(75-85)(76-77)(76-79)(76-85)(83-87)(84-87)(85-87)(86-87)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 10 | 9.1 | 10.1016/j.jinorgbio.2024.11254... | 2024 |
| SGC-7901 | 11 | 3.2 | 10.1016/j.jinorgbio.2024.11254... | 2024 |
| LO2 | 53 | 29 | 10.1016/j.jinorgbio.2024.11254... | 2024 |
🧬 Cell Death Types (2)
Apoptosis
high
«we investigated apoptosis and ferroptosis pathways, observing ... The effects on mitochondrial membrane potential and intracellular Ca2+ concentrations were also examined, revealing that both light-ac...»
Ferroptosis
high
«we investigated apoptosis and ferroptosis pathways, observing an increase in malondialdehyde (MDA) levels, a reduction of glutathione (GSH), a down-regulation of GPX4 (glutathione peroxidase) expressi...»