Info
| ID | 5952 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | 4a |
| SMILES | Nc1nc(N)c2nc3c4cccnc4c4ncccc4c3nc2n1.[c-]1cccc2ccc3cccnc3c12.[c-]1cccc2ccc3cccnc3c12 |
TUCAN
C42H26IrN10/(1-55)(2-30)(3-29)(4-57)(5-32)(6-37)(7-35)(8-34)(9-31)(10-39)(11-46)(12-58)(13-36)(14-44)(15-33)(16-45)(17-42)(18-56)(19-43)(20-40)(21-41)(22-38)(23-69)(24-69)(25-70)(26-70)(27-37)(27-47)(28-40)(28-52)(29-30)(29-48)(30-55)(31-32)(31-50)(32-37)(33-35)(33-49)(34-39)(34-48)(35-57)(36-43)(36-51)(38-44)(38-53)(39-50)(40-44)(41-45)(41-49)(42-46)(42-54)(43-58)(45-53)(46-56)(47-50)(47-59)(48-59)(49-64)(51-61)(51-65)(52-53)(52-64)(54-60)(54-63)(55-75)(56-73)(57-76)(58-72)(59-75)(60-61)(60-73)(61-72)(62-66)(62-67)(62-78)(63-65)(63-78)(64-76)(65-74)(66-71)(66-74)(67-70)(67-77)(68-69)(68-71)(68-77)(75-79)(76-79)(77-79)(78-79)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| SGC-7901 | — | 18 | 10.1016/j.jinorgbio.2024.11254... | 2024 |
| A549 | — | 84 | 10.1016/j.jinorgbio.2024.11254... | 2024 |
| LO2 | — | — | 10.1016/j.jinorgbio.2024.11254... | 2024 |
🧬 Cell Death Types (2)
Apoptosis
high
«we investigated apoptosis and ferroptosis pathways, observing ... The effects on mitochondrial membrane potential and intracellular Ca2+ concentrations were also examined, revealing that both light-ac...»
Ferroptosis
high
«we investigated apoptosis and ferroptosis pathways, observing an increase in malondialdehyde (MDA) levels, a reduction of glutathione (GSH), a down-regulation of GPX4 (glutathione peroxidase) expressi...»