Info
| ID | 5948 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ir4 |
| SMILES | O=C(Nc1cc2cccnc2c2ncccc12)c1ccccn1.[c-]1ccsc1-c1ccccn1.[c-]1ccsc1-c1ccccn1 |
TUCAN
C36H24IrN6OS2/(1-27)(2-28)(3-40)(4-49)(5-45)(6-29)(7-39)(8-35)(9-34)(10-36)(11-31)(12-41)(13-46)(14-47)(15-37)(16-33)(17-38)(18-32)(19-30)(20-48)(21-42)(22-57)(23-58)(24-62)(25-29)(25-59)(26-39)(26-60)(27-28)(27-33)(28-45)(29-57)(30-34)(30-46)(31-42)(31-51)(32-43)(32-50)(33-53)(34-38)(35-40)(35-44)(36-41)(36-48)(37-42)(37-49)(38-54)(39-58)(40-47)(41-43)(43-52)(44-50)(44-55)(45-63)(46-64)(47-66)(48-65)(49-61)(50-62)(51-56)(51-61)(52-55)(52-65)(53-59)(53-63)(54-60)(54-64)(55-66)(56-62)(56-67)(57-68)(58-69)(59-68)(60-69)(63-70)(64-70)(65-70)(66-70)(68-70)(69-70)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 4.3 | — | 10.1016/j.jinorgbio.2023.11239... | 2023 |
| HepG2 | 4.7 | — | 10.1016/j.jinorgbio.2023.11239... | 2023 |
| HeLa | 5.1 | — | 10.1016/j.jinorgbio.2023.11239... | 2023 |
| MCF-7 | 6.6 | — | 10.1016/j.jinorgbio.2023.11239... | 2023 |
| LO2 | 16 | — | 10.1016/j.jinorgbio.2023.11239... | 2023 |
🧬 Cell Death Types (2)
Apoptosis
high
«Further investigations revealed that Ir2 could simultaneously induce both apoptosis and autophagy in A549 cells»
Autophagy
high
«Further investigations revealed that Ir2 could simultaneously induce both apoptosis and autophagy in A549 cells, with the latter acting as a non-protective mechanism that promoted cell death.»