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Complex #5947 — Ir(3) [Ir3]

2D Structure

Structure
⬇ MOL V3000

Info

ID5947
MetalIr
Oxidation state3
Charge1
Donor atoms{"N": 6}
AbbreviationIr3
SMILESFc1c[c-]c(-c2ccccn2)c(F)c1.Fc1c[c-]c(-c2ccccn2)c(F)c1.O=C(Nc1cc2cccnc2c2ncccc12)c1ccccn1

TUCAN

C40H24F4IrN6O/(1-37)(2-50)(3-52)(4-49)(5-36)(6-28)(7-40)(8-43)(9-27)(10-32)(11-30)(12-29)(13-31)(14-34)(15-33)(16-42)(17-44)(18-51)(19-38)(20-41)(21-35)(22-39)(23-53)(24-66)(25-30)(25-46)(26-44)(26-48)(27-33)(27-52)(28-31)(28-50)(29-61)(29-62)(30-62)(31-36)(32-37)(32-49)(33-47)(34-38)(34-45)(35-41)(35-43)(36-54)(37-40)(38-51)(39-47)(39-56)(40-58)(41-59)(42-63)(42-64)(43-53)(44-64)(45-56)(45-57)(46-54)(46-61)(47-55)(48-59)(48-63)(49-65)(50-69)(51-68)(52-67)(53-70)(54-69)(55-57)(55-67)(56-66)(57-68)(58-60)(58-65)(59-70)(60-66)(60-71)(61-72)(62-73)(63-74)(64-75)(67-76)(68-76)(69-76)(70-76)

Measurements (5)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
A5495.2 10.1016/j.jinorgbio.2023.11239... 2023
MCF-75.9 10.1016/j.jinorgbio.2023.11239... 2023
HeLa6.3 10.1016/j.jinorgbio.2023.11239... 2023
HepG27.8 10.1016/j.jinorgbio.2023.11239... 2023
LO217 10.1016/j.jinorgbio.2023.11239... 2023

🧬 Cell Death Types (2)

Apoptosis high
«Further investigations revealed that Ir2 could simultaneously induce both apoptosis and autophagy in A549 cells»
Autophagy high
«Further investigations revealed that Ir2 could simultaneously induce both apoptosis and autophagy in A549 cells, with the latter acting as a non-protective mechanism that promoted cell death.»