Info
| ID | 5941 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 7} |
| Abbreviation | Ir3 |
| SMILES | Nc1ccc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)cc1.[c-]1cccc2ccc3cccnc3c12.[c-]1cccc2ccc3cccnc3c12 |
TUCAN
C45H29IrN7/(1-33)(2-49)(3-34)(4-63)(5-32)(6-37)(7-44)(8-42)(9-41)(10-50)(11-47)(12-65)(13-52)(14-53)(15-45)(16-36)(17-40)(18-66)(19-51)(20-64)(21-48)(22-46)(23-43)(24-35)(25-38)(26-39)(27-75)(28-77)(29-75)(30-34)(30-55)(31-42)(31-57)(32-36)(32-63)(33-34)(33-37)(35-44)(35-54)(36-54)(37-59)(38-45)(38-56)(39-40)(39-66)(40-56)(41-50)(41-61)(42-49)(43-49)(43-60)(44-59)(45-60)(46-53)(46-61)(47-51)(47-62)(48-52)(48-58)(50-72)(51-65)(52-64)(53-72)(54-67)(55-59)(55-67)(56-71)(57-60)(57-71)(58-69)(58-70)(61-74)(62-68)(62-73)(63-79)(64-76)(65-78)(66-80)(67-79)(68-69)(68-78)(69-76)(70-73)(70-77)(71-80)(72-75)(73-81)(74-77)(74-81)(78-82)(79-82)(80-82)(81-82)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HOS | 7.4 | — | 10.1016/j.jinorgbio.2022.11201... | 2022 |
| U2OS | 9.5 | — | 10.1016/j.jinorgbio.2022.11201... | 2022 |
| MG-63 | 9.5 | — | 10.1016/j.jinorgbio.2022.11201... | 2022 |
| HepG2 | 15 | — | 10.1016/j.jinorgbio.2022.11201... | 2022 |
| LO2 | 32 | — | 10.1016/j.jinorgbio.2022.11201... | 2022 |
🧬 Cell Death Types (2)
Apoptosis
high
«These results demonstrated that the complexes can cause apoptosis in HOS cells.»
Autophagy
high
«which suggests that the complexes can cause autophagy.»