Info
| ID | 5940 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 7} |
| Abbreviation | Ir2 |
| SMILES | Nc1ccccc1-c1nc2c3cccnc3c3ncccc3c2[nH]1.[c-]1cccc2ccc3cccnc3c12.[c-]1cccc2ccc3cccnc3c12 |
TUCAN
C45H29IrN7/(1-32)(2-50)(3-42)(4-33)(5-63)(6-43)(7-34)(8-37)(9-45)(10-47)(11-52)(12-41)(13-48)(14-64)(15-49)(16-46)(17-36)(18-38)(19-65)(20-40)(21-53)(22-66)(23-44)(24-35)(25-51)(26-39)(27-77)(28-75)(29-75)(30-33)(30-55)(31-43)(31-58)(32-33)(32-37)(34-36)(34-63)(35-45)(35-54)(36-54)(37-59)(38-39)(38-57)(39-65)(40-41)(40-61)(41-47)(42-49)(42-56)(43-50)(44-50)(44-60)(45-59)(46-51)(46-60)(47-52)(48-53)(48-62)(49-66)(51-57)(52-71)(53-64)(54-67)(55-59)(55-67)(56-68)(56-70)(57-73)(58-60)(58-73)(61-71)(61-74)(62-69)(62-72)(63-78)(64-79)(65-80)(66-76)(67-78)(68-69)(68-76)(69-79)(70-72)(70-77)(71-75)(72-81)(73-80)(74-77)(74-81)(78-82)(79-82)(80-82)(81-82)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HOS | 10 | — | 10.1016/j.jinorgbio.2022.11201... | 2022 |
| MG-63 | 20 | — | 10.1016/j.jinorgbio.2022.11201... | 2022 |
| U2OS | 28 | — | 10.1016/j.jinorgbio.2022.11201... | 2022 |
| HepG2 | — | — | 10.1016/j.jinorgbio.2022.11201... | 2022 |
| LO2 | — | — | 10.1016/j.jinorgbio.2022.11201... | 2022 |
🧬 Cell Death Types (2)
Apoptosis
high
«These results demonstrated that the complexes can cause apoptosis in HOS cells.»
Autophagy
high
«which suggests that the complexes can cause autophagy.»