Info
| ID | 5939 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 7} |
| Abbreviation | Ir1 |
| SMILES | Nc1cccc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)c1.[c-]1cccc2ccc3cccnc3c12.[c-]1cccc2ccc3cccnc3c12 |
TUCAN
C45H29IrN7/(1-33)(2-34)(3-48)(4-63)(5-32)(6-38)(7-44)(8-42)(9-45)(10-51)(11-40)(12-52)(13-66)(14-41)(15-50)(16-35)(17-37)(18-65)(19-46)(20-64)(21-47)(22-53)(23-49)(24-36)(25-43)(26-39)(27-77)(28-75)(29-75)(30-34)(30-55)(31-48)(31-56)(32-35)(32-63)(33-34)(33-38)(35-54)(36-44)(36-54)(37-39)(37-57)(38-59)(39-65)(40-45)(40-61)(41-47)(41-58)(42-48)(42-49)(43-50)(43-57)(44-59)(45-51)(46-52)(46-62)(47-66)(49-60)(50-60)(51-72)(52-64)(53-61)(53-72)(54-67)(55-59)(55-67)(56-60)(56-71)(57-71)(58-68)(58-70)(61-74)(62-69)(62-73)(63-79)(64-78)(65-80)(66-76)(67-79)(68-69)(68-76)(69-78)(70-73)(70-77)(71-80)(72-75)(73-81)(74-77)(74-81)(78-82)(79-82)(80-82)(81-82)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HOS | 22 | — | 10.1016/j.jinorgbio.2022.11201... | 2022 |
| U2OS | 28 | — | 10.1016/j.jinorgbio.2022.11201... | 2022 |
| MG-63 | 31 | — | 10.1016/j.jinorgbio.2022.11201... | 2022 |
| HepG2 | 96 | — | 10.1016/j.jinorgbio.2022.11201... | 2022 |
| LO2 | — | — | 10.1016/j.jinorgbio.2022.11201... | 2022 |
🧬 Cell Death Types (2)
Apoptosis
high
«These results demonstrated that the complexes can cause apoptosis in HOS cells.»
Autophagy
high
«which suggests that the complexes can cause autophagy.»