Info
| ID | 5937 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"N": 2} |
| Abbreviation | Ir11 |
| SMILES | COc1c[c-]c(-c2nc3c4ccccc4c4ccccc4c3n2-c2ccc(C)cc2)cc1.Cc1c(C)c(C)[c-](C)c1C.[Cl-] |
TUCAN
C39H36IrN2O/(1-37)(2-37)(3-37)(4-48)(5-38)(6-38)(7-38)(8-39)(9-39)(10-44)(11-40)(12-47)(13-50)(14-39)(15-41)(16-46)(17-45)(18-51)(19-49)(20-41)(21-41)(22-42)(23-42)(24-40)(25-58)(26-40)(27-56)(28-74)(29-74)(30-74)(31-52)(32-42)(33-55)(34-53)(35-54)(36-57)(37-59)(38-60)(39-61)(40-63)(41-64)(42-65)(43-56)(43-68)(44-49)(44-75)(45-48)(45-62)(46-47)(46-63)(47-71)(48-52)(49-68)(50-51)(50-71)(51-63)(52-53)(53-66)(54-55)(54-67)(55-57)(56-75)(57-58)(58-69)(59-60)(59-61)(60-64)(61-65)(62-66)(62-70)(64-65)(66-67)(67-69)(68-73)(69-72)(70-72)(70-76)(71-76)(72-77)(73-76)(73-77)(74-78)(75-78)(77-79)(78-79)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 97 | — | 10.1016/j.jinorgbio.2024.11261... | 2024 |
| BEAS-2B | — | — | 10.1016/j.jinorgbio.2024.11261... | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«Western blotting further confirmed that complexes could induce A549 cell apoptosis through the lysosomal-mitochondrial anticancer pathway»