Info
| ID | 5936 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"N": 2} |
| Abbreviation | Ir10 |
| SMILES | Cc1c(-c2ccccc2)c(C)[c-](C)c1C.Cc1ccc(-n2c(-c3[c-]cccc3)nc3c4ccccc4c4ccccc4c32)cc1.[Cl-] |
TUCAN
C43ClIrN2/(1-32)(2-30)(3-34)(4-37)(5-38)(6-24)(6-36)(7-13)(7-35)(8-16)(8-30)(9-10)(9-11)(10-31)(11-19)(12-23)(12-29)(13-14)(14-26)(15-20)(15-25)(16-42)(17-20)(17-39)(18-26)(18-35)(19-21)(21-31)(22-27)(22-42)(23-24)(25-33)(27-30)(28-31)(28-32)(28-37)(29-36)(29-40)(32-34)(33-39)(33-41)(34-38)(35-43)(36-39)(37-38)(40-41)(40-44)(41-45)(42-45)(43-44)(43-45)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 16 | — | 10.1016/j.jinorgbio.2024.11261... | 2024 |
| BEAS-2B | 24 | — | 10.1016/j.jinorgbio.2024.11261... | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«Western blotting further confirmed that complexes could induce A549 cell apoptosis through the lysosomal-mitochondrial anticancer pathway»