Info
| ID | 5934 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"N": 2} |
| Abbreviation | Ir8 |
| SMILES | Cc1c(-c2ccccc2)c(C)[c-](C)c1C.Cc1ccc(-n2c(-c3[c-]cc(F)cc3)nc3c4ccccc4c4ccccc4c32)cc1.[Cl-] |
TUCAN
C43ClFIrN2/(1-28)(2-30)(3-38)(4-37)(5-35)(6-18)(6-21)(7-9)(7-20)(8-9)(8-29)(10-11)(10-31)(11-43)(12-25)(12-34)(13-15)(13-25)(14-17)(14-43)(15-33)(16-19)(16-41)(17-31)(18-24)(19-37)(20-22)(21-36)(22-29)(23-26)(23-41)(24-32)(26-37)(27-29)(27-30)(27-35)(28-30)(28-38)(31-42)(32-34)(32-36)(33-34)(33-40)(35-38)(36-39)(39-40)(39-44)(40-45)(41-45)(42-44)(42-45)(43-46)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 15 | — | 10.1016/j.jinorgbio.2024.11261... | 2024 |
| BEAS-2B | 26 | — | 10.1016/j.jinorgbio.2024.11261... | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«Western blotting further confirmed that complexes could induce A549 cell apoptosis through the lysosomal-mitochondrial anticancer pathway»