Info
| ID | 5933 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"N": 2} |
| Abbreviation | Ir7 |
| SMILES | Cc1c(C)c(C)[c-](C)c1C.Cc1ccc(-n2c(-c3[c-]cc(F)cc3)nc3c4ccccc4c4ccccc4c32)cc1.[Cl-] |
TUCAN
C38ClFIrN2/(1-23)(2-25)(3-30)(4-26)(5-31)(6-32)(7-8)(7-33)(8-38)(9-14)(9-33)(10-21)(10-29)(11-12)(11-21)(12-28)(13-19)(13-36)(14-38)(15-18)(15-20)(16-22)(16-36)(17-18)(17-24)(19-30)(20-27)(22-30)(23-25)(23-26)(24-27)(24-34)(25-31)(26-32)(27-29)(28-29)(28-35)(31-32)(33-37)(34-35)(34-39)(35-40)(36-40)(37-39)(37-40)(38-41)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| BEAS-2B | 19 | — | 10.1016/j.jinorgbio.2024.11261... | 2024 |
| A549 | 23 | — | 10.1016/j.jinorgbio.2024.11261... | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«Western blotting further confirmed that complexes could induce A549 cell apoptosis through the lysosomal-mitochondrial anticancer pathway»