Info
| ID | 5932 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | Ir6 |
| SMILES | COc1ccc(-c2nc3c4cccnc4c4ncccc4c3n2-c2ccc(C)cc2)cc1.Cc1c(-c2ccccc2)c(C)[c-](C)c1C.[Cl-] |
TUCAN
C42H37IrN4O/(1-38)(2-39)(3-39)(4-38)(5-38)(6-39)(7-42)(8-42)(9-54)(10-44)(11-41)(12-55)(13-45)(14-41)(15-42)(16-49)(17-46)(18-41)(19-43)(20-40)(21-57)(22-40)(23-47)(24-58)(25-59)(26-78)(27-78)(28-78)(29-70)(30-48)(31-52)(32-50)(33-53)(34-40)(35-51)(36-71)(37-56)(38-61)(39-64)(40-63)(41-65)(42-66)(43-45)(43-46)(44-45)(44-62)(46-55)(47-54)(47-79)(48-49)(48-63)(49-72)(50-51)(50-68)(51-70)(52-53)(52-63)(53-72)(54-69)(55-62)(56-57)(56-71)(57-67)(58-59)(58-69)(59-79)(60-61)(60-62)(60-66)(61-64)(64-65)(65-66)(67-75)(67-76)(68-73)(68-74)(69-77)(70-80)(71-82)(72-81)(73-76)(73-81)(74-75)(74-80)(75-82)(76-83)(77-81)(77-83)(78-84)(79-84)(82-85)(83-85)(84-85)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 11 | — | 10.1016/j.jinorgbio.2024.11261... | 2024 |
| BEAS-2B | 35 | — | 10.1016/j.jinorgbio.2024.11261... | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«Western blotting further confirmed that complexes could induce A549 cell apoptosis through the lysosomal-mitochondrial anticancer pathway»