Info
| ID | 5931 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | Ir5 |
| SMILES | COc1ccc(-c2nc3c4cccnc4c4ncccc4c3n2-c2ccc(C)cc2)cc1.Cc1c(C)c(C)[c-](C)c1C.[Cl-] |
TUCAN
C37H35IrN4O/(1-36)(2-36)(3-36)(4-39)(5-37)(6-37)(7-37)(8-43)(9-49)(10-38)(11-38)(12-38)(13-40)(14-40)(15-40)(16-39)(17-42)(18-41)(19-41)(20-41)(21-45)(22-47)(23-44)(24-48)(25-46)(26-39)(27-51)(28-71)(29-71)(30-71)(31-63)(32-53)(33-64)(34-52)(35-50)(36-54)(37-55)(38-58)(39-57)(40-59)(41-60)(42-43)(42-65)(43-57)(44-45)(44-72)(45-61)(46-49)(46-65)(47-48)(47-56)(48-63)(49-57)(50-51)(50-61)(51-72)(52-53)(52-64)(53-62)(54-55)(54-58)(55-59)(56-66)(56-67)(58-60)(59-60)(61-70)(62-68)(62-69)(63-73)(64-75)(65-74)(66-69)(66-74)(67-68)(67-73)(68-75)(69-76)(70-74)(70-76)(71-77)(72-77)(75-78)(76-78)(77-78)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| BEAS-2B | 97 | — | 10.1016/j.jinorgbio.2024.11261... | 2024 |
| A549 | — | — | 10.1016/j.jinorgbio.2024.11261... | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«Western blotting further confirmed that complexes could induce A549 cell apoptosis through the lysosomal-mitochondrial anticancer pathway»