Info
| ID | 5930 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | Ir4 |
| SMILES | Cc1c(-c2ccccc2)c(C)[c-](C)c1C.Cc1ccc(-n2c(-c3ccccc3)nc3c4cccnc4c4ncccc4c32)cc1.[Cl-] |
TUCAN
C41H35IrN4/(1-40)(2-40)(3-40)(4-36)(5-48)(6-36)(7-36)(8-39)(9-43)(10-54)(11-69)(12-56)(13-46)(14-70)(15-47)(16-44)(17-53)(18-41)(19-42)(20-57)(21-55)(22-58)(23-45)(24-52)(25-37)(26-50)(27-39)(28-49)(29-37)(30-37)(31-38)(32-38)(33-39)(34-38)(35-51)(36-61)(37-60)(38-62)(39-67)(40-68)(41-45)(41-70)(42-43)(42-44)(43-59)(44-55)(45-65)(46-47)(46-68)(47-72)(48-49)(48-63)(49-50)(50-51)(51-52)(52-63)(53-58)(53-72)(54-57)(54-64)(55-56)(56-59)(57-69)(58-68)(59-76)(60-61)(60-62)(61-66)(62-67)(63-66)(64-71)(64-73)(65-74)(65-75)(66-67)(69-77)(70-80)(71-75)(71-78)(72-78)(73-74)(73-77)(74-80)(75-79)(76-78)(76-79)(79-81)(80-81)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 16 | — | 10.1016/j.jinorgbio.2024.11261... | 2024 |
| BEAS-2B | 27 | — | 10.1016/j.jinorgbio.2024.11261... | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«Western blotting further confirmed that complexes could induce A549 cell apoptosis through the lysosomal-mitochondrial anticancer pathway»