Info
| ID | 5929 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | Ir3 |
| SMILES | Cc1c(C)c(C)[c-](C)c1C.Cc1ccc(-n2c(-c3ccccc3)nc3c4cccnc4c4ncccc4c32)cc1.[Cl-] |
TUCAN
C36H33IrN4/(1-39)(2-39)(3-39)(4-34)(5-34)(6-34)(7-35)(8-35)(9-35)(10-36)(11-36)(12-42)(13-49)(14-63)(15-46)(16-41)(17-62)(18-43)(19-40)(20-51)(21-50)(22-44)(23-48)(24-45)(25-52)(26-47)(27-36)(28-37)(29-37)(30-37)(31-38)(32-38)(33-38)(34-53)(35-54)(36-55)(37-58)(38-59)(39-60)(40-44)(40-45)(41-43)(41-60)(42-44)(42-61)(43-68)(45-46)(46-61)(47-50)(47-57)(48-49)(48-63)(49-56)(50-62)(51-52)(51-68)(52-60)(53-54)(53-55)(54-58)(55-59)(56-64)(56-66)(57-65)(57-67)(58-59)(61-69)(62-73)(63-70)(64-65)(64-71)(65-72)(66-67)(66-70)(67-73)(68-71)(69-71)(69-72)(72-74)(73-74)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 58 | — | 10.1016/j.jinorgbio.2024.11261... | 2024 |
| BEAS-2B | 72 | — | 10.1016/j.jinorgbio.2024.11261... | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«Western blotting further confirmed that complexes could induce A549 cell apoptosis through the lysosomal-mitochondrial anticancer pathway»