Info
| ID | 5928 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | Ir2 |
| SMILES | Cc1c(-c2ccccc2)c(C)[c-](C)c1C.Cc1ccc(-n2c(-c3ccc(F)cc3)nc3c4cccnc4c4ncccc4c32)cc1.[Cl-] |
TUCAN
C41H34FIrN4/(1-50)(2-35)(3-35)(4-35)(5-51)(6-43)(7-41)(8-56)(9-39)(10-68)(11-40)(12-46)(13-55)(14-39)(15-48)(16-47)(17-42)(18-44)(19-67)(20-54)(21-39)(22-45)(23-52)(24-36)(25-38)(26-36)(27-36)(28-38)(29-38)(30-37)(31-37)(32-49)(33-37)(34-53)(35-60)(36-59)(37-61)(38-65)(39-66)(40-46)(40-66)(41-47)(41-67)(42-43)(42-57)(43-75)(44-45)(44-57)(45-75)(46-70)(47-58)(48-54)(48-70)(49-50)(49-62)(50-51)(51-52)(52-53)(53-62)(54-66)(55-56)(55-63)(56-68)(57-74)(58-69)(58-72)(59-60)(59-61)(60-64)(61-65)(62-64)(63-71)(63-73)(64-65)(67-76)(68-79)(69-73)(69-77)(70-77)(71-72)(71-79)(72-76)(73-78)(74-77)(74-78)(75-80)(78-81)(79-81)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 18 | — | 10.1016/j.jinorgbio.2024.11261... | 2024 |
| BEAS-2B | 38 | — | 10.1016/j.jinorgbio.2024.11261... | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«Western blotting further confirmed that complexes could induce A549 cell apoptosis through the lysosomal-mitochondrial anticancer pathway»