Info
| ID | 5920 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ir2 |
| SMILES | O=c1c(-c2nc3c4cccnc4c4ncccc4c3[nH]2)coc2ccccc12.[c-]1cccc2ccc3cccnc3c12.[c-]1cccc2ccc3cccnc3c12 |
TUCAN
C48H28IrN6O2/(1-31)(2-43)(3-34)(4-48)(5-36)(6-41)(7-50)(8-44)(9-63)(10-74)(11-64)(12-51)(13-65)(14-40)(15-46)(16-39)(17-47)(18-32)(19-35)(20-45)(21-66)(22-37)(23-52)(24-38)(25-49)(26-33)(27-42)(28-78)(29-41)(29-56)(30-49)(30-59)(31-34)(31-63)(32-36)(32-53)(33-44)(33-53)(34-54)(35-50)(35-55)(36-54)(37-40)(37-65)(38-39)(38-46)(39-58)(40-57)(41-44)(42-47)(42-55)(43-48)(43-64)(45-51)(45-62)(46-52)(47-49)(48-60)(50-60)(51-66)(52-75)(53-56)(54-67)(55-59)(56-67)(57-71)(57-72)(58-75)(58-76)(59-70)(60-70)(61-73)(61-74)(61-76)(62-68)(62-69)(63-79)(64-80)(65-77)(66-82)(67-79)(68-72)(68-81)(69-71)(69-82)(70-80)(71-77)(72-78)(73-78)(73-81)(74-84)(75-84)(76-83)(79-85)(80-85)(81-85)(82-85)(84-85)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 | 6.1 | — | 10.3390/molecules27175434 | 2022 |
| LO2 | 41 | — | 10.3390/molecules27175434 | 2022 |
🧬 Cell Death Types (4)
Apoptosis
high
«the results show that the complexes can effectively induce apoptosis.»
Autophagy
high
«The results show that the complexes can effectively induce autophagy.»
Ferroptosis
high
«the results show that the complexes can trigger oxidant stress and further induce ferroptosis.»
Immunogenic Cell Death
high
«Hence, the complexes can induce immunogenic cell death.»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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