Info
| ID | 5920 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ir2 |
| SMILES | O=c1c(-c2nc3c4cccnc4c4ncccc4c3[nH]2)coc2ccccc12.[c-]1cccc2ccc3cccnc3c12.[c-]1cccc2ccc3cccnc3c12 |
TUCAN
C48H28IrN6O2/(1-31)(2-43)(3-34)(4-48)(5-36)(6-41)(7-50)(8-44)(9-63)(10-74)(11-64)(12-51)(13-65)(14-40)(15-46)(16-39)(17-47)(18-32)(19-35)(20-45)(21-66)(22-37)(23-52)(24-38)(25-49)(26-33)(27-42)(28-78)(29-41)(29-56)(30-49)(30-59)(31-34)(31-63)(32-36)(32-53)(33-44)(33-53)(34-54)(35-50)(35-55)(36-54)(37-40)(37-65)(38-39)(38-46)(39-58)(40-57)(41-44)(42-47)(42-55)(43-48)(43-64)(45-51)(45-62)(46-52)(47-49)(48-60)(50-60)(51-66)(52-75)(53-56)(54-67)(55-59)(56-67)(57-71)(57-72)(58-75)(58-76)(59-70)(60-70)(61-73)(61-74)(61-76)(62-68)(62-69)(63-79)(64-80)(65-77)(66-82)(67-79)(68-72)(68-81)(69-71)(69-82)(70-80)(71-77)(72-78)(73-78)(73-81)(74-84)(75-84)(76-83)(79-85)(80-85)(81-85)(82-85)(84-85)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 | 6.1 | — | 10.3390/molecules27175434 | 2022 |
| LO2 | 41 | — | 10.3390/molecules27175434 | 2022 |
🧬 Cell Death Types (4)
Apoptosis
high
«the results show that the complexes can effectively induce apoptosis.»
Autophagy
high
«The results show that the complexes can effectively induce autophagy.»
Ferroptosis
high
«the results show that the complexes can trigger oxidant stress and further induce ferroptosis.»
Immunogenic Cell Death
high
«Hence, the complexes can induce immunogenic cell death.»