Info
| ID | 5908 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"N": 5, "O": 1} |
| Abbreviation | Ir3 |
| SMILES | Fc1c[c-]c(-c2ccccn2)c(F)c1.Fc1c[c-]c(-c2ccccn2)c(F)c1.[O-]N=C(c1ccccn1)c1ccccn1 |
TUCAN
C33H20F4IrN5O/(1-32)(2-29)(3-27)(4-34)(5-44)(6-25)(7-41)(8-36)(9-23)(10-28)(11-43)(12-26)(13-31)(14-38)(15-35)(16-42)(17-24)(18-30)(19-33)(20-37)(21-28)(21-39)(22-35)(22-40)(23-32)(23-46)(24-30)(24-42)(25-31)(25-41)(26-32)(26-44)(27-50)(27-51)(28-50)(29-31)(29-47)(30-34)(33-52)(33-53)(34-49)(35-52)(36-37)(36-48)(37-38)(38-43)(39-47)(39-51)(40-48)(40-53)(41-55)(42-56)(43-57)(44-54)(45-46)(45-49)(45-58)(46-54)(47-55)(48-57)(49-56)(50-61)(51-60)(52-63)(53-62)(55-64)(56-64)(57-64)(58-59)(58-64)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 21 | — | 10.1039/d5ra03076e | 2025 |
| HT-29 | 27 | — | 10.1039/d5ra03076e | 2025 |
| LN229 | 31 | — | 10.1039/d5ra03076e | 2025 |
🧬 Cell Death Types (1)
Apoptosis
high
«Immunocytochemistry analysis revealed that the iridium complexes induced the upregulation and nuclear localization of the tumor suppressor protein p53, as well as the activation of cleaved caspase, a ...»