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Complex #5863 — Ir(3) [8]

2D Structure

Structure
⬇ MOL V3000

Info

ID5863
MetalIr
Oxidation state3
Charge1
Donor atoms{"N": 5}
Abbreviation8
SMILESCc1c(C)c(C)[c-](C)c1C.[c-]1cccc2c1c1ncccc1c1nc3cc4ccccc4cc3nc21.c1ccc(Cn2ccnc2)cc1

TUCAN

C43H37IrN5/(1-51)(2-50)(3-38)(4-38)(5-38)(6-39)(7-39)(8-73)(9-45)(10-80)(11-58)(12-59)(13-74)(14-44)(15-57)(16-48)(17-56)(18-53)(19-49)(20-46)(21-71)(22-47)(23-39)(24-40)(25-40)(26-40)(27-41)(28-41)(29-54)(30-72)(31-52)(32-74)(33-55)(34-41)(35-42)(36-42)(37-42)(38-61)(39-62)(40-63)(41-64)(42-65)(43-53)(43-67)(44-45)(44-69)(45-47)(46-60)(46-75)(47-52)(48-49)(48-60)(49-56)(50-56)(50-66)(51-66)(51-78)(52-57)(53-55)(54-55)(54-68)(57-69)(58-59)(58-70)(59-73)(60-66)(61-62)(61-63)(62-64)(63-65)(64-65)(67-68)(67-79)(68-77)(69-74)(70-76)(70-79)(71-72)(71-82)(72-84)(73-85)(74-82)(75-78)(75-83)(76-77)(76-83)(77-81)(78-81)(79-85)(80-82)(80-84)(83-86)(84-86)(85-86)

Measurements (7)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
A5490.150.0002 10.1021/acs.jmedchem.3c01276 2024
A5490.150.0021 10.1021/acs.jmedchem.3c01276 2024
A5490.150.03 10.1021/acs.jmedchem.3c01276 2024
1BR.3.G0.50.0005 10.1021/acs.jmedchem.3c01276 2024
HeLa0.510.0008 10.1021/acs.jmedchem.3c01276 2024
PC-30.640.0005 10.1021/acs.jmedchem.3c01276 2024
MRC-50.680.0008 10.1021/acs.jmedchem.3c01276 2024

🧬 Cell Death Types (1)

Apoptosis high
«Consequently, cell death by apoptosis and secondary necrosis is activated.»