Info
| ID | 5860 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | 5 |
| SMILES | Cc1c(C)c(C)[c-](C)c1C.[c-]1cccc2c1c1ncccc1c1nc3ccccc3nc21.c1cn(CCN2CCCCC2)cn1 |
TUCAN
C39H42IrN6/(1-43)(2-43)(3-43)(4-44)(5-44)(6-55)(7-54)(8-53)(9-52)(10-72)(11-72)(12-57)(13-51)(14-58)(15-75)(16-58)(17-49)(18-56)(19-71)(20-50)(21-73)(22-60)(23-75)(24-44)(25-45)(26-45)(27-45)(28-46)(29-46)(30-46)(31-47)(32-47)(33-69)(34-59)(35-73)(36-74)(37-59)(38-74)(39-70)(40-60)(41-81)(42-47)(43-61)(44-62)(45-63)(46-64)(47-65)(48-55)(48-66)(49-50)(49-77)(50-57)(51-57)(51-79)(52-56)(52-67)(53-54)(53-68)(54-55)(56-71)(58-60)(58-72)(59-60)(59-75)(61-62)(61-63)(62-64)(63-65)(64-65)(66-68)(66-78)(67-78)(67-80)(68-76)(69-70)(69-85)(70-84)(71-86)(72-83)(73-74)(73-83)(74-84)(75-83)(76-80)(76-82)(77-79)(77-82)(78-86)(79-87)(80-87)(81-84)(81-85)(85-88)(86-88)(87-88)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 0.83 | 0.39 | 10.1021/acs.jmedchem.3c01276 | 2024 |
| A549 | 0.83 | 0.52 | 10.1021/acs.jmedchem.3c01276 | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«Consequently, cell death by apoptosis and secondary necrosis is activated.»