Info
| ID | 5852 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ir4 |
| SMILES | CN(C)c1ccc(-c2c[c-]c(-c3nc4ccccc4n3Cc3ccc(C(F)(F)F)cc3)s2)cc1.CN(C)c1ccc(-c2c[c-]c(-c3nc4ccccc4n3Cc3ccc(C(F)(F)F)cc3)s2)cc1.c1ccc2nc3c4cccnc4c4ncccc4c3nc2c1 |
TUCAN
C72H52F6IrN10S2/(1-61)(2-59)(3-60)(4-58)(5-63)(6-73)(7-64)(8-103)(9-97)(10-86)(11-102)(12-101)(13-67)(14-55)(15-81)(16-82)(17-65)(18-62)(19-72)(20-71)(21-103)(22-74)(23-69)(24-77)(25-97)(26-80)(27-84)(28-104)(29-97)(30-98)(31-75)(32-70)(33-56)(34-85)(35-98)(36-98)(37-99)(38-99)(39-99)(40-100)(41-57)(42-66)(43-79)(44-100)(45-76)(46-68)(47-83)(48-100)(49-87)(50-88)(51-104)(52-78)(53-65)(53-123)(54-74)(54-124)(55-61)(55-76)(56-84)(56-113)(57-63)(57-92)(58-60)(58-106)(59-61)(59-108)(60-91)(62-64)(62-91)(63-95)(64-106)(65-121)(66-71)(66-92)(67-86)(67-89)(68-77)(68-93)(69-72)(69-94)(70-75)(70-90)(71-95)(72-116)(73-84)(73-85)(74-122)(75-101)(76-110)(77-96)(78-83)(78-111)(79-80)(79-116)(80-94)(81-82)(81-83)(82-109)(85-115)(86-102)(87-88)(87-93)(88-96)(89-105)(89-107)(90-112)(90-114)(91-121)(92-119)(93-120)(94-122)(95-103)(96-104)(97-128)(98-128)(99-129)(100-129)(101-131)(102-125)(103-127)(104-130)(105-112)(105-125)(106-128)(107-114)(107-126)(108-110)(108-132)(109-111)(109-133)(110-127)(111-130)(112-131)(113-115)(113-134)(114-134)(115-126)(116-129)(117-123)(117-127)(117-132)(118-124)(118-130)(118-133)(119-135)(119-136)(119-137)(120-138)(120-139)(120-140)(121-141)(122-142)(123-141)(124-142)(131-143)(132-143)(133-143)(134-143)(141-143)(142-143)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | — | 3.7 | 10.1021/acs.jmedchem.3c01978 | 2023 |
| HCT-116 | — | 3.4 | 10.1021/acs.jmedchem.3c01978 | 2023 |
| A375 | — | 2.6 | 10.1021/acs.jmedchem.3c01978 | 2023 |
| MRC-5 | — | — | 10.1021/acs.jmedchem.3c01978 | 2023 |
🧬 Cell Death Types (1)
Oncosis
high
«when irradiated, the complexes induced leakage of lysosomal content into the cytoplasm of HeLa cancer cells and induced oncosis-like cell death.»