Info
| ID | 5850 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 8} |
| Abbreviation | Ir2 |
| SMILES | CN(C)c1ccc(-c2c[c-]c(-c3nc4ccccc4s3)s2)cc1.CN(C)c1ccc(-c2c[c-]c(-c3nc4ccccc4s3)s2)cc1.c1ccc2nc3c4cccnc4c4ncccc4c3nc2c1 |
TUCAN
C56H40IrN8S4/(1-43)(2-62)(3-46)(4-50)(5-73)(6-63)(7-73)(8-73)(9-44)(10-77)(11-48)(12-54)(13-57)(14-47)(15-51)(16-53)(17-74)(18-61)(19-64)(20-65)(21-68)(22-74)(23-78)(24-74)(25-49)(26-66)(27-52)(28-45)(29-55)(30-58)(31-75)(32-75)(33-75)(34-76)(35-76)(36-76)(37-60)(38-56)(39-67)(40-59)(41-45)(41-89)(42-56)(42-92)(43-46)(43-83)(44-52)(44-71)(45-90)(46-70)(47-50)(47-57)(48-54)(48-83)(49-55)(49-85)(50-53)(51-65)(51-68)(52-77)(53-79)(54-70)(55-72)(56-94)(57-91)(58-59)(58-85)(59-72)(60-63)(60-69)(61-65)(61-93)(62-64)(62-67)(63-78)(64-66)(66-87)(67-86)(68-88)(69-82)(69-84)(70-90)(71-80)(71-81)(72-94)(73-99)(74-99)(75-100)(76-100)(77-97)(78-101)(79-91)(79-102)(80-84)(80-97)(81-82)(81-98)(82-103)(83-99)(84-101)(85-100)(86-87)(86-103)(87-98)(88-93)(88-104)(89-95)(89-105)(90-105)(91-107)(92-96)(92-106)(93-108)(94-106)(95-102)(95-107)(96-104)(96-108)(101-109)(102-109)(103-109)(104-109)(105-109)(106-109)(107-109)(108-109)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | — | 0.7 | 10.1021/acs.jmedchem.3c01978 | 2023 |
| HCT-116 | — | 0.77 | 10.1021/acs.jmedchem.3c01978 | 2023 |
| A375 | — | 0.4 | 10.1021/acs.jmedchem.3c01978 | 2023 |
| MRC-5 | — | — | 10.1021/acs.jmedchem.3c01978 | 2023 |
| HeLa | — | 4.3 | 10.1021/acs.jmedchem.3c01978 | 2023 |
| HeLa | — | 8.5 | 10.1021/acs.jmedchem.3c01978 | 2023 |
🧬 Cell Death Types (1)
Oncosis
high
«when irradiated, the complexes induced leakage of lysosomal content into the cytoplasm of HeLa cancer cells and induced oncosis-like cell death.»