Info
| ID | 5849 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ir1 |
| SMILES | FC(F)(F)c1ccc(-c2c[c-]c(-c3nc4ccccc4s3)s2)cc1.FC(F)(F)c1ccc(-c2c[c-]c(-c3nc4ccccc4s3)s2)cc1.c1ccc2nc3c4cccnc4c4ncccc4c3nc2c1 |
TUCAN
C54H28F6IrN6S4/(1-64)(2-40)(3-31)(4-42)(5-46)(6-53)(7-33)(8-49)(9-45)(10-48)(11-47)(12-51)(13-35)(14-52)(15-54)(16-37)(17-32)(18-63)(19-38)(20-56)(21-55)(22-43)(23-34)(24-50)(25-41)(26-39)(27-36)(28-44)(29-44)(29-77)(30-42)(30-76)(31-40)(31-58)(32-49)(32-63)(33-51)(33-69)(34-41)(34-78)(35-43)(35-57)(36-54)(36-68)(37-45)(37-59)(38-55)(38-59)(39-50)(39-57)(40-64)(41-46)(42-75)(43-60)(44-79)(45-62)(46-52)(47-48)(47-51)(48-70)(49-61)(50-60)(52-71)(53-54)(53-56)(55-62)(56-80)(57-75)(58-65)(58-66)(59-74)(60-73)(61-67)(61-72)(62-79)(63-83)(64-85)(65-67)(65-85)(66-72)(66-86)(67-83)(68-80)(68-87)(69-70)(69-84)(70-86)(71-78)(71-88)(72-84)(73-89)(73-90)(73-93)(74-91)(74-92)(74-94)(75-96)(76-81)(76-96)(77-82)(77-97)(78-95)(79-97)(80-98)(81-88)(81-95)(82-87)(82-98)(85-99)(86-99)(87-99)(88-99)(97-99)(98-99)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | — | 0.31 | 10.1021/acs.jmedchem.3c01978 | 2023 |
| HCT-116 | — | 0.3 | 10.1021/acs.jmedchem.3c01978 | 2023 |
| A375 | — | 0.18 | 10.1021/acs.jmedchem.3c01978 | 2023 |
| MRC-5 | — | — | 10.1021/acs.jmedchem.3c01978 | 2023 |
🧬 Cell Death Types (1)
Oncosis
high
«when irradiated, the complexes induced leakage of lysosomal content into the cytoplasm of HeLa cancer cells and induced oncosis-like cell death.»