Info
| ID | 5836 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ir-TRF |
| SMILES | Fc1cc(F)cc(-c2cn(-c3ccccn3)nn2)c1.[c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1 |
TUCAN
C35H24F2IrN6/(1-29)(2-35)(3-50)(4-36)(5-28)(6-34)(7-27)(8-30)(9-42)(10-40)(11-43)(12-45)(13-31)(14-39)(15-53)(16-41)(17-37)(18-46)(19-32)(20-38)(21-52)(22-33)(23-44)(24-51)(25-27)(25-47)(26-40)(26-48)(27-28)(28-41)(29-36)(29-50)(30-36)(30-54)(31-49)(31-58)(32-39)(32-53)(33-40)(33-44)(34-41)(34-47)(35-42)(35-52)(37-44)(37-48)(38-49)(38-59)(39-46)(42-43)(43-55)(45-58)(45-59)(46-57)(47-54)(48-55)(49-56)(50-62)(51-56)(51-61)(52-63)(53-64)(54-62)(55-63)(56-60)(57-61)(57-64)(58-66)(59-67)(60-65)(61-65)(62-68)(63-68)(64-68)(65-68)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| ME-180 | 11 | — | 10.1021/acs.jmedchem.4c01997 | 2024 |
| A549 | 18 | — | 10.1021/acs.jmedchem.4c01997 | 2024 |
| HaCaT | 66 | — | 10.1021/acs.jmedchem.4c01997 | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«The complexes increase the ROS generation within the cell, further supporting apoptotic induction by exerting cellular oxidative stress. These metal complexes also affect ER stress by altering ERp29, ...»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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