Info
| ID | 5835 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ir-TRH |
| SMILES | [c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1.c1ccc(-c2cn(-c3ccccn3)nn2)cc1 |
TUCAN
C35H26IrN6/(1-35)(2-33)(3-30)(4-54)(5-40)(6-37)(7-48)(8-31)(9-47)(10-39)(11-34)(12-56)(13-29)(14-49)(15-50)(16-38)(17-43)(18-55)(19-57)(20-45)(21-44)(22-32)(23-36)(24-46)(25-41)(26-42)(27-34)(27-51)(28-49)(28-53)(29-37)(29-58)(30-37)(30-56)(31-33)(31-38)(32-43)(32-61)(33-52)(34-40)(35-36)(35-40)(36-51)(38-44)(39-43)(39-54)(41-47)(41-57)(42-46)(42-48)(44-45)(45-52)(46-53)(47-50)(48-49)(50-59)(51-58)(52-60)(53-59)(54-65)(55-60)(55-63)(56-64)(57-66)(58-64)(59-66)(60-62)(61-63)(61-65)(62-67)(63-67)(64-68)(65-68)(66-68)(67-68)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| ME-180 | 14 | — | 10.1021/acs.jmedchem.4c01997 | 2024 |
| A549 | 32 | — | 10.1021/acs.jmedchem.4c01997 | 2024 |
| HaCaT | 66 | — | 10.1021/acs.jmedchem.4c01997 | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«The complexes increase the ROS generation within the cell, further supporting apoptotic induction by exerting cellular oxidative stress. These metal complexes also affect ER stress by altering ERp29, ...»