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Complex #5820 — Ir(3) [2a]

2D Structure

Structure
⬇ MOL V3000

Info

ID5820
MetalIr
Oxidation state3
Charge1
Donor atoms{"N": 7}
Abbreviation2a
SMILESC=C/[C-]=C(\C)c1nc2ccccc2[nH]1.C=C/[C-]=C(\C)c1nc2ccccc2[nH]1.CCCCn1c(-c2ccc3ccccc3n2)nc2cc(C(=O)OC)ccc21

TUCAN

C46H43IrN7O2/(1-46)(2-54)(3-76)(4-88)(5-70)(6-47)(7-52)(8-44)(9-58)(10-46)(11-46)(12-48)(13-53)(14-57)(15-76)(16-88)(17-70)(18-55)(19-48)(20-56)(21-69)(22-65)(23-64)(24-51)(25-71)(26-47)(27-61)(28-88)(29-71)(30-63)(31-62)(32-59)(33-60)(34-47)(35-66)(36-67)(37-44)(38-48)(39-45)(40-45)(41-68)(42-90)(43-91)(44-56)(45-69)(46-72)(47-70)(48-73)(49-56)(49-72)(50-69)(50-73)(51-60)(51-78)(52-55)(52-64)(53-54)(53-77)(54-57)(55-63)(57-58)(58-80)(59-62)(59-79)(60-75)(61-74)(61-81)(62-74)(63-75)(64-82)(65-67)(65-83)(66-67)(66-68)(68-84)(70-71)(71-76)(72-86)(73-87)(74-89)(75-82)(76-92)(77-80)(77-90)(78-85)(78-94)(79-81)(79-92)(80-95)(81-93)(82-94)(83-84)(83-96)(84-91)(85-92)(85-93)(86-90)(86-95)(87-91)(87-96)(88-98)(89-97)(89-98)(93-99)(94-99)(95-99)(96-99)(98-99)

Measurements (5)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
A375—2.1 10.1021/acs.jmedchem.3c00189 2023
SK-MEL-28—2.8 10.1021/acs.jmedchem.3c00189 2023
HeLa—75 10.1021/acs.jmedchem.3c00189 2023
A2780—4 10.1021/acs.jmedchem.3c00189 2023
A2780cisR—3.5 10.1021/acs.jmedchem.3c00189 2023