Info
| ID | 5818 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | YQ3 |
| SMILES | COc1ccc(/C=C/c2nc3c4cccnc4c4ncccc4c3[nH]2)cc1.[c-]1ccccc1-c1nccc2ccccc12.[c-]1ccccc1-c1nccc2ccccc12 |
TUCAN
C52H36IrN6O/(1-48)(2-39)(3-56)(4-42)(5-60)(6-78)(7-50)(8-51)(9-63)(10-62)(11-41)(12-59)(13-79)(14-52)(15-43)(16-58)(17-64)(18-87)(19-87)(20-87)(21-65)(22-76)(23-46)(24-44)(25-49)(26-54)(27-40)(28-66)(29-77)(30-45)(31-53)(32-61)(33-55)(34-47)(35-57)(36-90)(37-50)(37-67)(38-59)(38-69)(39-51)(39-68)(40-55)(40-70)(41-56)(41-67)(42-60)(42-71)(43-65)(43-73)(44-47)(44-74)(45-46)(45-76)(46-72)(47-88)(48-50)(48-56)(49-62)(49-75)(51-60)(52-71)(52-78)(53-75)(53-79)(54-61)(54-69)(55-62)(57-66)(57-88)(58-64)(58-86)(59-63)(61-63)(64-74)(65-77)(66-74)(67-80)(68-71)(68-80)(69-81)(70-75)(70-81)(72-84)(72-85)(73-82)(73-83)(76-89)(77-94)(78-91)(79-92)(80-91)(81-92)(82-84)(82-93)(83-85)(83-94)(84-90)(85-89)(86-90)(86-93)(87-95)(88-95)(91-96)(92-96)(93-96)(94-96)(95-96)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A375 | — | 0.27 | 10.1021/acs.inorgchem.3c02364 | 2023 |
| A549 | — | 0.72 | 10.1021/acs.inorgchem.3c02364 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«YQ2 could enter cells ... activate caspases, and induce apoptosis.»