Info
| ID | 5817 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"O": 1, "N": 6} |
| Abbreviation | YQ2 |
| SMILES | O=[N+]([O-])c1ccc(/C=C/c2nc3c4cccnc4c4ncccc4c3[nH]2)cc1.[c-]1ccccc1-c1nccc2ccccc12.[c-]1ccccc1-c1nccc2ccccc12 |
TUCAN
C51H33IrN7O2/(1-38)(2-37)(3-41)(4-74)(5-36)(6-40)(7-48)(8-51)(9-60)(10-59)(11-52)(12-42)(13-43)(14-44)(15-45)(16-61)(17-76)(18-47)(19-56)(20-50)(21-49)(22-62)(23-63)(24-54)(25-73)(26-46)(27-39)(28-75)(29-58)(30-57)(31-55)(32-53)(33-86)(34-48)(34-64)(35-60)(35-66)(36-51)(36-68)(37-42)(37-64)(38-41)(38-65)(39-49)(39-67)(40-68)(40-74)(41-51)(42-52)(43-50)(43-66)(44-45)(44-71)(45-80)(46-47)(46-72)(47-73)(48-52)(49-57)(50-58)(53-63)(53-71)(54-61)(54-76)(55-62)(55-71)(56-70)(56-75)(57-59)(58-60)(59-70)(61-69)(62-80)(63-84)(64-77)(65-68)(65-77)(66-78)(67-70)(67-78)(69-79)(69-83)(72-81)(72-82)(73-85)(74-90)(75-91)(76-89)(77-90)(78-91)(79-81)(79-88)(80-87)(81-86)(82-83)(82-85)(83-89)(84-86)(84-88)(87-92)(87-93)(88-94)(89-94)(90-94)(91-94)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A375 | — | 0.11 | 10.1021/acs.inorgchem.3c02364 | 2023 |
| A549 | — | 0.081 | 10.1021/acs.inorgchem.3c02364 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«YQ2 could enter cells ... activate caspases, and induce apoptosis.»