Info
| ID | 5813 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"O": 1, "N": 6} |
| Abbreviation | YP2 |
| SMILES | O=[N+]([O-])c1ccc(/C=C/c2nc3c4cccnc4c4ncccc4c3[nH]2)cc1.[c-]1ccccc1-c1ccc2ccccc2n1.[c-]1ccccc1-c1ccc2ccccc2n1 |
TUCAN
C51H33IrN7O2/(1-38)(2-36)(3-46)(4-39)(5-61)(6-45)(7-49)(8-58)(9-59)(10-37)(11-47)(12-50)(13-60)(14-52)(15-65)(16-54)(17-63)(18-74)(19-43)(20-62)(21-48)(22-56)(23-57)(24-64)(25-53)(26-73)(27-42)(28-55)(29-51)(30-40)(31-41)(32-44)(33-86)(34-49)(34-67)(35-59)(35-68)(36-39)(36-67)(37-40)(37-75)(38-46)(38-76)(39-47)(40-66)(41-50)(41-68)(42-43)(42-70)(43-73)(44-56)(44-71)(45-46)(45-48)(47-49)(48-66)(50-60)(51-61)(51-78)(52-62)(52-72)(53-63)(53-74)(54-65)(54-72)(55-64)(55-72)(56-77)(57-58)(57-71)(58-61)(59-60)(62-81)(63-69)(64-81)(65-84)(66-76)(67-75)(68-77)(69-80)(69-83)(70-79)(70-82)(71-78)(73-85)(74-91)(75-88)(76-88)(77-89)(78-89)(79-80)(79-86)(80-90)(81-87)(82-83)(82-85)(83-91)(84-86)(84-90)(87-92)(87-93)(88-94)(89-94)(90-94)(91-94)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A375 | — | 0.27 | 10.1021/acs.inorgchem.3c02364 | 2023 |
| A549 | — | 0.18 | 10.1021/acs.inorgchem.3c02364 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«YQ2 could enter cells ... activate caspases, and induce apoptosis.»