Info
| ID | 581 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | Ru8 |
| SMILES | CC(C)(C)c1ccc(/N=C/c2ccccc2[NH-])cc1.Cc1ccc(C(C)C)cc1 |
TUCAN
C27H33N2Ru/(1-35)(2-48)(3-43)(4-56)(5-34)(6-35)(7-41)(8-35)(9-36)(10-34)(11-36)(12-40)(13-34)(14-37)(15-50)(16-47)(17-37)(18-37)(19-38)(20-46)(21-51)(22-38)(23-45)(24-42)(25-49)(26-36)(27-44)(28-38)(29-39)(30-58)(31-39)(32-39)(33-61)(34-52)(35-56)(36-56)(37-57)(38-57)(39-57)(40-41)(40-54)(41-52)(42-49)(42-52)(43-48)(43-60)(44-45)(44-59)(45-46)(46-47)(47-53)(48-55)(49-54)(50-51)(50-60)(51-55)(53-58)(53-59)(54-56)(55-57)(58-62)(59-61)(60-62)(61-63)(62-63)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 9.1 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| HeLa | 9.9 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| A549cisR | 10 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| HepG2 | 13 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| BEAS-2B | 22 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«Further, the induction of cell apoptosis and the perturbation of the cell cycle in the G0/G1 phase were also observed for these complexes.»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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