Info
| ID | 58 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"S": 2, "O": 2, "N": 3} |
| Abbreviation | 1 |
| SMILES | CS(C)=O.CS(C)=O.Nc1ccccc1-c1nc2ccccc2[nH]1.[Cl-].[Cl-] |
TUCAN
C17H23N3O2RuS2/(1-26)(2-31)(3-24)(4-37)(5-37)(6-37)(7-38)(8-38)(9-38)(10-30)(11-27)(12-39)(13-39)(14-25)(15-28)(16-29)(17-39)(18-40)(19-40)(20-40)(21-42)(22-41)(23-41)(24-27)(24-30)(25-26)(25-29)(26-31)(27-28)(28-34)(29-32)(30-33)(31-35)(32-35)(32-36)(33-34)(33-42)(34-43)(35-41)(36-42)(36-43)(37-46)(38-46)(39-47)(40-47)(43-48)(44-46)(45-47)(46-48)(47-48)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| Caco-2 | 2.9e+02 | — | 10.3390/molecules25184284 | 2020 |
| MCF-7 | 3.2e+02 | — | 10.3390/molecules25184284 | 2020 |
| THLE-2 | 1.8e+03 | — | 10.3390/molecules25184284 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«An apoptosis mechanism was determined by the observation of increased Bax and caspase 3 and decreased Bcl2 expression.»