Info
| ID | 5796 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"O": 1, "N": 2} |
| Abbreviation | Ir-2 |
| SMILES | CC(=O)/C=C(/C)[O-].[c-]1c(-c2ccccn2)sc2ccccc12.[c-]1c(-c2ccccn2)sc2ccccc12 |
TUCAN
C31H23IrN2O2S2/(1-30)(2-34)(3-35)(4-32)(5-40)(6-45)(7-38)(8-39)(9-46)(10-37)(11-24)(12-24)(13-24)(14-25)(15-36)(16-33)(17-41)(18-29)(19-42)(20-28)(21-25)(22-31)(23-25)(24-49)(25-50)(26-44)(26-52)(27-43)(27-53)(28-37)(28-51)(29-30)(29-38)(30-34)(31-49)(31-50)(32-36)(32-42)(33-37)(33-40)(34-54)(35-39)(35-41)(36-48)(38-44)(39-47)(40-43)(41-45)(42-46)(43-51)(44-54)(45-55)(46-56)(47-52)(47-55)(48-53)(48-56)(49-57)(50-58)(51-60)(52-59)(53-60)(54-59)(55-61)(56-61)(60-61)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 14 | — | 10.3389/fphar.2025.1562228 | 2025 |
| NCI-H1299 | — | — | 10.3389/fphar.2025.1562228 | 2025 |
| BEAS-2B | — | — | 10.3389/fphar.2025.1562228 | 2025 |
🧬 Cell Death Types (1)
Apoptosis
high
«Mechanistic studies showed that Ir-1 enhanced radiation-induced cancer cell death by disrupting mitochondrial function and activating the mitochondrial apoptotic pathway. This was evidenced by upregul...»