Info
| ID | 5795 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"O": 1, "N": 4} |
| Abbreviation | Ir-1 |
| SMILES | CC(=O)/C=C(/C)[O-].Cc1cnc2c3[c-]cccc3c3ccccc3c2n1.Cc1cnc2c3[c-]cccc3c3ccccc3c2n1 |
TUCAN
C39H29IrN4O2/(1-38)(2-37)(3-59)(4-42)(5-31)(6-41)(7-31)(8-31)(9-32)(10-39)(11-30)(12-30)(13-60)(14-47)(15-36)(16-46)(17-30)(18-40)(19-32)(20-50)(21-33)(22-33)(23-43)(24-45)(25-44)(26-49)(27-33)(28-48)(29-32)(30-64)(31-67)(32-68)(33-65)(34-38)(34-51)(35-43)(35-54)(36-40)(36-53)(37-42)(37-52)(38-47)(39-47)(39-57)(40-42)(41-67)(41-68)(43-50)(44-50)(44-58)(45-46)(45-56)(46-49)(48-49)(48-55)(51-57)(51-63)(52-53)(52-61)(53-57)(54-58)(54-66)(55-56)(55-58)(56-62)(59-64)(59-70)(60-65)(60-72)(61-63)(61-69)(62-66)(62-71)(63-70)(64-69)(65-71)(66-72)(67-73)(68-74)(69-75)(70-75)(71-75)(72-75)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 11 | — | 10.3389/fphar.2025.1562228 | 2025 |
| NCI-H1299 | 54 | — | 10.3389/fphar.2025.1562228 | 2025 |
| BEAS-2B | — | — | 10.3389/fphar.2025.1562228 | 2025 |
🧬 Cell Death Types (1)
Apoptosis
high
«Mechanistic studies showed that Ir-1 enhanced radiation-induced cancer cell death by disrupting mitochondrial function and activating the mitochondrial apoptotic pathway. This was evidenced by upregul...»