Info
| ID | 5786 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | IrThpy@L1 |
| SMILES | O=C(OCc1ccnc(-c2cc(COC(=O)c3cc4cc(Cl)ccc4[nH]3)ccn2)c1)c1cc2cc(Cl)ccc2[nH]1.[c-]1ccsc1-c1ccccn1.[c-]1ccsc1-c1ccccn1 |
TUCAN
C48H32Cl2IrN6O4S2/(1-36)(2-75)(3-35)(4-44)(5-71)(6-45)(7-39)(8-76)(9-43)(10-51)(11-40)(12-50)(13-42)(14-71)(15-46)(16-72)(17-47)(18-60)(19-59)(20-72)(21-53)(22-52)(23-37)(24-61)(25-48)(26-54)(27-38)(28-62)(29-41)(30-49)(31-81)(32-82)(33-35)(33-77)(34-39)(34-78)(35-75)(36-37)(36-64)(37-50)(38-54)(38-65)(39-76)(40-57)(40-60)(41-56)(41-61)(42-44)(42-63)(43-57)(43-69)(44-79)(45-55)(45-79)(46-55)(46-67)(47-58)(47-68)(48-58)(48-80)(49-53)(49-66)(50-59)(51-56)(51-70)(52-54)(52-62)(53-80)(55-63)(56-71)(57-72)(58-66)(59-83)(60-85)(61-86)(62-84)(63-81)(64-77)(64-83)(65-78)(65-84)(66-82)(67-73)(67-81)(68-74)(68-82)(69-70)(69-85)(70-86)(71-89)(72-90)(73-87)(73-89)(74-88)(74-90)(75-91)(76-92)(77-91)(78-92)(79-93)(80-94)(83-95)(84-95)(85-95)(86-95)(89-95)(90-95)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 | 1.9 | — | 10.1021/acs.inorgchem.4c03950 | 2024 |
| HepG2 | 2.1 | — | 10.1021/acs.inorgchem.4c03950 | 2024 |
| HeLa | 4.1 | — | 10.1021/acs.inorgchem.4c03950 | 2024 |
| A549 | 6.2 | — | 10.1021/acs.inorgchem.4c03950 | 2024 |
| WRL68 | 44 | — | 10.1021/acs.inorgchem.4c03950 | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«activate a cascade of mitochondria-mediated cell death events, and arrest the cell cycle in S-phase which leads to apoptosis.»