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Complex #5785 — Ir(3) [IrBzq@L2]

2D Structure

Structure
⬇ MOL V3000

Info

ID5785
MetalIr
Oxidation state3
Charge1
Donor atoms{"N": 4}
AbbreviationIrBzq@L2
SMILESO=C(OCc1ccnc(-c2cc(COC(=O)c3sc4ccccc4c3Cl)ccn2)c1)c1sc2ccccc2c1Cl.[c-]1cccc2ccc3cccnc3c12.[c-]1cccc2ccc3cccnc3c12

TUCAN

C56H34Cl2IrN4O4S2/(1-39)(2-44)(3-50)(4-54)(5-73)(6-46)(7-37)(8-38)(9-40)(10-52)(11-81)(12-74)(13-55)(14-48)(15-45)(16-42)(17-75)(18-81)(19-49)(20-76)(21-82)(22-47)(23-53)(24-62)(25-51)(26-41)(27-60)(28-61)(29-82)(30-57)(31-58)(32-56)(33-43)(34-59)(35-38)(35-63)(36-43)(36-66)(37-39)(37-64)(38-39)(40-44)(40-65)(41-43)(41-45)(42-46)(42-65)(44-64)(45-72)(46-73)(47-51)(47-85)(48-50)(48-51)(49-67)(49-79)(50-68)(52-67)(52-74)(53-57)(53-58)(54-59)(54-72)(55-60)(55-76)(56-57)(56-88)(58-69)(59-70)(60-70)(61-71)(61-80)(62-71)(62-75)(63-64)(63-77)(65-77)(66-72)(66-78)(67-81)(68-85)(68-89)(69-88)(69-90)(70-78)(71-82)(73-91)(74-92)(75-93)(76-94)(77-91)(78-94)(79-80)(79-92)(80-93)(81-97)(82-98)(83-86)(83-95)(83-97)(84-87)(84-96)(84-98)(85-99)(86-89)(86-99)(87-90)(87-100)(88-100)(89-101)(90-102)(91-103)(92-103)(93-103)(94-103)

Measurements (5)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
HCT-1162.2 10.1021/acs.inorgchem.4c03950 2024
HepG23.4 10.1021/acs.inorgchem.4c03950 2024
HeLa4.9 10.1021/acs.inorgchem.4c03950 2024
A5499 10.1021/acs.inorgchem.4c03950 2024
WRL68 10.1021/acs.inorgchem.4c03950 2024

🧬 Cell Death Types (1)

Apoptosis high
«activate a cascade of mitochondria-mediated cell death events, and arrest the cell cycle in S-phase which leads to apoptosis.»