Info
| ID | 578 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | Ru5 |
| SMILES | COc1ccc(/N=C/c2ccccc2N)cc1.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C24H28N2ORu/(1-29)(2-32)(3-29)(4-30)(5-29)(6-33)(7-31)(8-38)(9-31)(10-31)(11-30)(12-43)(13-36)(14-35)(15-37)(16-51)(17-48)(18-40)(19-51)(20-51)(21-30)(22-39)(23-47)(24-42)(25-34)(26-41)(27-53)(28-53)(29-47)(30-44)(31-47)(32-33)(32-44)(33-45)(34-37)(34-49)(35-36)(35-46)(36-43)(37-52)(38-39)(38-45)(39-44)(40-43)(40-50)(41-42)(41-49)(42-52)(45-47)(46-48)(46-50)(48-54)(49-54)(50-53)(51-55)(52-55)(54-56)(55-56)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 6.2 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| A549 | 6.6 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| A549cisR | 8.3 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| HepG2 | 9.3 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
| BEAS-2B | 21 | — | 10.1021/acs.inorgchem.3c03471 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«Further, the induction of cell apoptosis and the perturbation of the cell cycle in the G0/G1 phase were also observed for these complexes.»