Info
| ID | 5773 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 5} |
| Abbreviation | Ir-Me |
| SMILES | COC(=O)/C=C/c1ccc(-c2nccc3c4ccccc4n(C)c23)nc1.[c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1 |
TUCAN
C43H33IrN5O2/(1-65)(2-46)(3-38)(4-36)(5-41)(6-37)(7-45)(8-66)(9-40)(10-64)(11-67)(12-48)(13-53)(14-58)(15-43)(16-49)(17-75)(18-56)(19-50)(20-42)(21-57)(22-64)(23-47)(24-55)(25-52)(26-75)(27-68)(28-51)(29-44)(30-64)(31-54)(32-39)(33-75)(34-46)(34-59)(35-55)(35-62)(36-37)(36-41)(37-46)(38-45)(38-65)(39-48)(39-52)(40-47)(40-66)(41-59)(42-44)(42-51)(43-58)(43-61)(44-57)(45-53)(47-54)(48-55)(49-56)(49-61)(50-60)(50-68)(51-63)(52-62)(53-69)(54-70)(56-76)(57-73)(58-74)(59-69)(60-63)(60-72)(61-67)(62-70)(63-73)(64-77)(65-78)(66-81)(67-80)(68-79)(69-78)(70-81)(71-72)(71-74)(71-79)(72-77)(73-77)(74-80)(75-83)(76-82)(76-83)(78-84)(79-84)(80-84)(81-84)(83-84)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 0.47 | 0.033 | 10.1021/acs.inorgchem.4c02583 | 2024 |
| MRC-5 | 1.1 | 0.031 | 10.1021/acs.inorgchem.4c02583 | 2024 |
| PC-3 | 1.2 | 0.072 | 10.1021/acs.inorgchem.4c02583 | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«Overall, these results indicated that the photodynamic activity of both the complexes and metallopeptides promotes a regulated cell death by apoptosis.»